期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 9, 页码 364-372出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.06.004
关键词
hypoxia; hypoxia-inducible factor; development; angiogenesis; cancer; stem cells
资金
- NIH [CA095060, CA098920]
Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription factors, HIF-1 and HIF-2, which have both overlapping and unique target genes. HIF target gene activation is highly context specific and is not a reliable indicator of which HIF-alpha isoform is active. For example, in some cell lines, the individual HIFs have specific temporal and functional roles: HIF-1 drives the initial response to hypoxia (<24 h) and HIF-2 drives the chronic response (>24 h). Here, we review the significance of the HIF switch and the relation between HIF-1 and HIF-2 under both physiological and pathophysiological conditions.
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