期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 7, 页码 263-273出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.04.001
关键词
-
资金
- National Institutes of Health (NIH) [GM062264, T32 GM007197]
The faithful expression of genes requires that cellular machinery select substrates with high specificity at each step in gene expression. High specificity is particularly important at the stage of nuclear pre-mRNA splicing, during which the spliceosome selects; splice sites and excises intervening introns. With low specificity, the usage of alternative sites would yield insertions, deletions and frame shifts in mRNA. Recently, biochemical, genetic and genome-wide approaches have significantly advanced our understanding of splicing fidelity. In particular, we have learned that DExD/H-box ATPases play a general role in rejecting and discarding suboptimal substrates and that these factors serve as a paradigm for proofreading NTPases in other systems. Recent advances have also defined fundamental questions for future investigations.
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