期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 10, 页码 411-417出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.07.004
关键词
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资金
- National Institutes of Health [RO1GM0999943-01]
- Ellison Medical Foundation
- Harvard University
Many eukaryotic membrane proteins have a single C-terminal transmembrane domain that anchors them to a variety of organelles in secretory and endocytic pathways. These tail-anchored (TA) proteins are post-translationally inserted into the endoplasmic reticulum by molecular mechanisms that have long remained mysterious. This review describes how, in just the past 5 years, intense research by a handful of laboratories has led to identification of all the key components of one such mechanism, the guided entry of TA proteins (GET) pathway, which is conserved from yeast to man. The GET pathway is both surprisingly complicated and yet more experimentally tractable than most other membrane insertion mechanisms, and is rapidly revealing new fundamental concepts in membrane protein biogenesis.
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