期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 6, 页码 215-219出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.02.006
关键词
-
资金
- National Institutes of Health Grant [NS16708]
- Israel Science Foundation [119/04]
It is usually assumed that to ensure proper function, membrane proteins must be inserted in a unique topology. However, a number of dimeric small multidrug transporters can function in the membrane in various topologies. Thus, the dimers can be a random mixture of NiCi (N and C termini facing the cell cytoplasm) and NoCo (N and C termini facing the outside) orientation. In addition, the dimer functions whether the two protomers are parallel (N and C termini of both protomers on the same side of the membrane) or antiparallel (N and C termini of each protomer on opposite sides of the membrane). This unique phenomenon provides strong support for a simple mechanism of transport where the directionality is determined solely by the driving force.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据