期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 36, 期 5, 页码 245-253出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2011.01.003
关键词
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资金
- Medical Research Council UK [G0601597]
- MRC [G0601597] Funding Source: UKRI
- Medical Research Council [G0601597] Funding Source: researchfish
S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.
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