期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 36, 期 8, 页码 415-423出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2011.04.006
关键词
-
资金
- Marie Curie Actions of the European FP7 [Human-MB08-A 80125]
Traditionally, specific DNA recognition is thought to rely on static contacts with the bases or phosphates. Recent results, however, indicate that residues far outside the binding context can crucially influence selectivity or binding affinity via transient, dynamic interactions with the DNA binding interface. These regions usually do not adopt a well-defined structure, even when bound to DNA, and thus form a fuzzy complex. Here, we propose the existence of a dynamic DNA readout mechanism, wherein distant segments modulate conformational preferences, flexibility or spacing of the DNA binding motifs or serve as competitive partners. Despite their low sequence similarity, these intrinsically disordered regions are often conserved at the structural level, and exploited for regulation of the transcription machinery via protein protein interactions, post-translational modifications or alternative splicing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据