期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 35, 期 4, 页码 236-245出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.10.003
关键词
-
资金
- National Institutes of Health [CA78590, CA111294, CA133774, CA131944]
- Department of Defense [PC081409, BC074639, BC083295]
Mucins are high molecular weight glycoproteins that are involved in regulating diverse cellular activities both in normal and pathological conditions. Mucin activity and localization is mediated by several molecular mechanisms, including discrete interactions with other proteins. An understanding of the biochemistry behind the known interactions between mucins and other proteins, coupled with an appreciation of their pathophysiological significance, can lend insight into the development of novel therapeutic agents. Indeed, a recent study demonstrated that a cell permeable inhibitor, PMIP, that disrupts the MUC1-EGFR interaction, is effective in killing breast cancer cells in vitro and in tumor models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据