期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 34, 期 5, 页码 264-272出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.01.010
关键词
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资金
- National Institutes of Health [GM041784, GM054099]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM054099, R01GM041784] Funding Source: NIH RePORTER
Homologous recombination (HR)-mediated DNA double-strand break repair maintains genome integrity. Although long-studied, an understanding of two essential steps in this process - the resection of DNA ends to produce recombinogenic 3' single-stranded DNA tails and the resolution of recombination intermediates-has remained elusive. Recent findings show an unexpected role for the Sgs1 (BLM) helicase and Dna2 nuclease in end resection, and provide mechanistic insight into the initiation of 5'-3' resection as well as its regulation by the cell cycle and the DNA damage response. Moreover, the identification of a novel Holliday junction resolvase, Yen1 (GENU and several helicases that dismantle strand invasion intermediates has increased the repertoire of nucleases and helicases capable of resolving recombination intermediates.
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