期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 33, 期 11, 页码 526-534出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2008.08.002
关键词
-
资金
- National Institutes of Health [CA0179094, CA095060, CA109552]
The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to hypoxia and its expression levels are tightly controlled through synthesis and degradation. It is widely accepted that HIF-1 alpha protein accumulation during hypoxia results from inhibition of its oxygen-dependent degradation by the von Hippel Lindau protein (pVHL) pathway. However, recent data describe new pVHL- or oxygen-independent mechanisms for HIF-1 alpha degradation. Furthermore, the hypoxia-induced increase in HIF-1 alpha levels is facilitated by the continued translation of HIF-1 alpha during hypoxia despite the global inhibition of protein translation. Recent work has contributed to an increased understanding of the mechanisms that control the translation and degradation of HIF-1 alpha under both normoxic and hypoxic conditions.
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