期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 33, 期 8, 页码 352-355出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2008.05.007
关键词
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资金
- Flanders Institute for Biotechnology (VIB)
- EC RTD [LSHB-CT-2005-019067, FP7-200767]
- Fonds Wetenschappelijke Onderzoek Vlaanderen [3G.0218.06, G.0133.05]
- Ghent University [BOF-GOA - 12.0505.02]
- [MRTN-CT-035624]
The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models.
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