期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 33, 期 2, 页码 51-57出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2007.10.008
关键词
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The T cell antigen receptor (TCR-CD3) is the most complex receptor known to date, consisting of eight transmembrane subunits. Its activation by an antigen is the initial step in an immune response. Here, we present the permissive geometry model explaining how antigen binding initiates intracellular signalling cascades. We propose that a dimeric antigen imposes its geometry on two TCR-CD3 receptors by simultaneously binding to both. This causes the TCR alpha beta subunits to rotate with respect to each other leading to displacement of the ectodomains of the associated CD3 dimers. This results in a scissor-like movement of the CD3 dimers that opens the cytoplasmic tails for interaction with signalling proteins, thus initiating signalling cascades.
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