期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 33, 期 2, 页码 71-79出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2007.10.005
关键词
-
资金
- British Heart Foundation Funding Source: Medline
- NCI NIH HHS [R01 CA094397, R01 CA047407] Funding Source: Medline
- NHLBI NIH HHS [R21 HL69726] Funding Source: Medline
Stress proteins (SPs) from the heat shock and glucose-regulated protein families are abundant intracellular molecules that have powerful extracellular roles as immune modulators. Mammalian immune cells encounter both identical (self) SPs and non-identical SPs derived from invading pathogens. Although such extracellular SPs can function as powerful immunological adjuvants, SPs, including Hsp60 and Hsp70, can also attenuate inflammatory disease via apparent effects on immunoregulatory T cell populations. It therefore seems that the immunostimulatory and immunosuppressive potential of extracellullar SPs depends on the context in which they are encountered by the cellular immune-response network. Conclusions regarding the immunobiology of these powerful immunomodulatory molecules must therefore take into account their dichotomous properties and their physiological role and importance must be interpreted in the context of the complex in vivo micro-environments in which these proteins exist.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据