期刊
ACTA NEUROPSYCHIATRICA
卷 28, 期 3, 页码 173-178出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/neu.2015.59
关键词
biomarker; D-serine; depression L-serine; NMDA receptor
资金
- grant Comprehensive Research on Disability, Japan Agency for Medical Research and Development (AMED), Japan [H26-Seishin-Ippan-015]
Objective: Glutamatergic neurotransmission via the N-methyl-D-aspartate (NMDA) receptor is integral to the pathophysiology of depression. This study was performed to examine whether amino acids related to NMDA receptor neurotransmission are altered in the serum of patients with depression. Method: We measured the serum levels of D-serine, L-serine, glycine, glutamate and glutamine in patients with depression (n = 70), and age-matched healthy subjects (n = 78). Results: Serum levels of D-serine and L-serine in patients with depression were significantly higher than those of healthy controls (p < 0.001). In contrast, serum levels of glycine, glutamate and glutamine did not differ between the two groups. Interestingly, the ratio of L-serine to glycine in patients was significantly higher than that of healthy controls (p < 0.001). Conclusion: This study suggests that serine enantiomers may be peripheral biomarkers for depression, and that abnormality in the D-serine-L-serine-glycine cycle plays a role in the pathophysiology of depression.
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