期刊
ACTA NEUROPSYCHIATRICA
卷 27, 期 4, 页码 213-220出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/neu.2015.11
关键词
amygdala; functional magnetic resonance imaging; magnetic resonance imaging; schizophrenia
资金
- Schizofreniforbundet
- Strategic Research Committee
- Karolinska Institutet
- Stockholm County Council, Sweden
- Svenska Lakaresallskapet (The Swedish Society of Medicine) [SLS-403101]
Objectives Negative symptoms in schizophrenia have been associated with structural and functional alterations of the amygdala. We hypothesised that there would be between-group differences in amygdala volume and neural activation patterns during processing of affective stimuli among patients with schizophrenia and healthy controls. We further hypothesised correlations between neuroimaging metrics and clinical ratings of negative symptoms in patients with schizophrenia. Methods We used structural and functional magnetic resonance imaging to assess volume and neural activation of the amygdala in 28 patients with schizophrenia and 28 healthy controls. Results We found no between-group differences in amygdala volume or neural activation. However, we found a significant negative correlation between emotional blunting and neural activation in the left amygdala during processing of positive affect. We also found a significant negative correlation between stereotyped thinking and the volume of right amygdala. Conclusion Our findings implicate the amygdala in a subgroup of negative symptoms in schizophrenia that are characterised by reduced expression with blunted affect and stereotyped thinking.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据