The Expression and Distribution of Xenogeneic Targeted Antigens on Porcine Bone Tissue

Objective. The objective of this study was to investigate the distribution of alpha-galactosyl (alpha-Gal), major histocompatibility complex (MHC)-I, and MHC-II antigens on adult porcine bone tissue. Methods. Distribution of alpha-Gal, MHC-I, and MHC-II antigens on porcine bone tissue were observed using immunohistochemistry. Results. alpha-Gal, MHC-I xenogeneic antigens were extensively observed on the surface of bone marrow cells, osteocytes, osteoblasts, and Harversian canals; MHC-II antigens were mainly expressed on bone marrow cells. Conclusion. alpha-Gal, MHC-I, and MHC-II are the main xenogeneic antigens that must be deleted to avoid xenogeneic immune reactions against bone xenografts.