期刊
TRANSPLANTATION PROCEEDINGS
卷 44, 期 4, 页码 1107-1109出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.transproceed.2012.01.088
关键词
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Aim. To investigate whether mouse bone marrow mesenchymal stem cells (BMC) stimulate liver regeneration after partial hepatectomy. Methods. Isolated BMCs were purified by density gradient centrifugation. We performed a 70% hepatectomy in male BALB/c mice followed by injection of BMCs into the portal vein (PV-BMC group), or the tail vein (IV-BMC group), or of saline into the portal vein (control group). Results. The wet weight of the liver remnant increased significantly in the PV-BMC group at 3 and 5 days after hepatectomy compared with the IV-BMC and control groups. The Ki-67 labeling index revealed that the increase to result from stimulation of DNA synthesis. The constitutive interleulcin-6 and hepatocyte growth factor mRNAs in the remnant liver tended to increase in the PV-BMC group at 3 days after hepatectomy. Conclusions. These results demonstrated that BMC injection into the portal vein enhanced liver growth after partial hepatectomy in mice.
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