期刊
TRANSPLANTATION PROCEEDINGS
卷 42, 期 9, 页码 S7-S12出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.transproceed.2010.07.040
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资金
- NCI NIH HHS [CA125550, R01 CA125550] Funding Source: Medline
- NIAAA NIH HHS [R01 AA013913, AA13913] Funding Source: Medline
- NIDDK NIH HHS [R01 DK062987, DK 61688, T32DK07760, T32 DK007760, R01 DK055001, DK62987, DK55001, R01 DK061688] Funding Source: Medline
Every year in the United States, 5000 renal transplant recipients start or restart dialysis because of the unusual propensity of these allografts to develop interstitial fibrosis and tubular atrophy (IF/TA) Although IF/TA often follows one or more identifiable events, our capacity to specifically treat, prevent, or even detect IF/TA at an early stage is poor These limitations are largely related to our lack of adequate tools to assess graft failure over time Data accumulated over the past 5 years have demonstrated that tubular epithelial cells may react to certain fibrogenic stimuli to engage in the process of epithelial-to-mesenchymal transition (EMT) In this review, we highlight the current view of EMT with a focus on both its role in the context of renal transplantation and the potential for utilizing markers of EMT to identify patients undergoing early IF/TA
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