期刊
TOXINS
卷 7, 期 12, 页码 5224-5235出版社
MDPI
DOI: 10.3390/toxins7124876
关键词
aflatoxin B-1; Caenorhabditis elegans; deoxynivalenol; fumonisin B-1; mycotoxins; T-2 toxin; zearalenone
资金
- National Cancer Institute, National Institutes of Health [CA 94683, CA 90997]
- Peanut CRSP from United States Agency for International Development [ECG-A00-13-00001-00]
Aflatoxins B-1 (AFB(1)), deoxynivalenol (DON), fumonisin B-1 (FB1), T-2 toxin (T-2), and zearalenone (ZEA) are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB(1) toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB(1), FB1, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model.
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