期刊
TRANSPLANTATION
卷 96, 期 1, 页码 10-16出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e3182869d2f
关键词
Obesity; Transplantation outcome; Alloimmunity
资金
- National Institutes of Health [AG039449]
- Instituto Carlos Slim de la Salud
- Charite Foundation
- International Academy of Life Sciences/German Academic Exchange Service
- German Research Foundation (Deutsche Forschungsgemeinschaft) [FL 703/1-1]
Obesity has become an increasing problem in healthcare worldwide with far-reaching consequences. More obese patients with irreversible end-stage organ failure undergo organ transplantation, and organs from obese donors are more frequently used. A growing body of evidence suggests more frequent postoperative complications and inferior patient and graft survival linked to obesity. More recently, adipose tissue has been linked to chronic inflammatory processes potentially impacting alloimmune responses and graft quality.
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