期刊
TRANSPLANTATION
卷 92, 期 8, 页码 930-935出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e31822d873d
关键词
Cytomegalovirus; Liver transplantation; Children; Preemptive therapy; Ganciclovir
资金
- Ministry of Education
- Ministry of Health, Labor and Welfare, Japan [21591403]
- Foundation for Growth Science, Japan
- National Center for Child Health and Development [21A-2, 21-04, 21 042]
- Grants-in-Aid for Scientific Research [21591403] Funding Source: KAKEN
Background. Cytomegalovirus (CMV) infection remains the most common and critical viral infection that occurs after liver transplantation (LT). The current set of guidelines recommends prophylaxis over a preemptive therapy for pediatric LT; however, the data regarding the optimal approach after LT in children are limited. Methods. We conducted a universal preemptive therapy for CMV infection in 113 children (median: 16 months) after live-donor LT at the largest pediatric LT center in Japan between November 2005 and August 2009. CMV-pp65 antigenemia was monitored weekly regardless of the subjects' CMV serostatus after LT, and ganciclovir therapy was initiated when CMV-pp65 antigenemia was positive. Results. The overall success rate of LT was 91.7%. CMV-pp65 antigenemia became positive in 37 (33%) recipients, and the positivity with their CMV serostatus was as follows: donor (D)+/recipient (R)-: 62%, D+/R+: 36%, D+/R+ : 11%, and D-/R-: 8%. Among the D+/R- (n = 29) and D+/R+ (n = 44) recipients, 38% (n = 11) and 64% (n = 28) recipients were able to avoid the use of ganciclovir, respectively. Human CMV disease was documented in six (5%) recipients, and they were successfully treated with ganciclovir without any sequelae. Conclusions. Auniversal preemptive therapy for CMV infection after live-donor LT was successful for reducing the use of antiviral agents and for controlling CMV infection and disease in children.
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