期刊
TRANSPLANTATION
卷 90, 期 2, 页码 105-112出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e3181e913c2
关键词
Transplantation; Biomarker; MicroRNA; Immune Monitoring; Diagnosis
资金
- NIAID, NIH [R37AI 51652, RO1AI72790]
- Fondation Centaure
MicroRNAs (miRNAs) are evolutionarily conserved, small (similar to 20-25 nucleotides), single-stranded molecules that suppress the expression of protein-coding genes by translational repression, messenger RNA degradation, or both. More than 700 miRNAs have been identified in the human genome. Amazingly, a single miRNA can regulate the expression of hundreds of mRNAs or proteins within a cell. The small RNAs are fast emerging as master regulators of innate and adaptive immunity and likely to play a pivotal role in transplantation. The clinical application of RNA sequencing (next-generation sequencing) should facilitate transcriptome profiling at an unprecedented resolution. We provide an overview of miRNA biology and their hypothesized roles in transplantation.
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