期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 4, 期 10, 页码 1223-1233出版社
WILEY
DOI: 10.5966/sctm.2015-0057
关键词
Neural progenitor cells; Brain perivascular cells; Brain pericytes; White matter; Hippocampus; Monolayer culture
资金
- Bundesministerium fur Bildung und Forschung [AZ: 01GN1006]
Brain perivascular cells have recently been identified as a novel mesodermal cell type in the human brain. These cells reside in the perivascular niche and were shown to have mesodermal and, to a lesser extent, tissue-specific differentiation potential. Mesenchymal stem cells (MSCs) are widely proposed for use in cell therapy in many neurological disorders; therefore, it is of importance to better understand the intrinsic MSC population of the human brain. We systematically characterized adult human brain-derived pericytes during in vitro expansion and differentiation and compared these cells with fetal and adult human brain-derived neural stem cells (NSCs) and adult human bone marrow-derived MSCs. We found that adult human brain pericytes, which can be isolated from the hippocampus and from subcortical white matter, are in contrast to adult human NSCs easily expandable in monolayer cultures and show many similarities to human bone marrow-derived MSCs both regarding both surface marker expression and after whole transcriptome profile. Human brain pericytes showed a negligible propensity for neuroectodermal differentiation under various differentiation conditions but efficiently generated mesodermal progeny. Consequently, human brain pericytes resemble bone marrow-derived MSCs and might be very interesting for possible autologous and endogenous stem cell-based treatment strategies and cell therapeutic approaches for treating neurological diseases. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:1223-1233
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