期刊
TRANSPLANTATION
卷 86, 期 5, 页码 738-744出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e318184112c
关键词
posttransplant Kaposi sarcoma; HHV-8; immunity; sirolimus
资金
- Italian Ministry for Education, Universities and Research (MIUR), Rome, Italy
- Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan, Italy
- European Commission's FP6 Life-Science-Health Programme [LSHC-CT-2005-018704]
- Programma Regione ER-Universita 2007-09
In nine patients with posttransplant Kaposi sarcoma (KS) T-cell responses to human herpesvirus (HHV)-8 latent and lytic antigens, as detected by enzyme-linked-immunospot (Elispot) assay, were absent at disease onset. Virus-specific T-cell responses were detected in six renal recipients at remission after a reduction of calcineurin inhibitors (CIs), and in two HHV-8 seropositive renal recipients without KS. In two liver recipients undergoing switch from CIs to sirolimus (SRL), normalization of the T-cell repertoire and recovery of both HHV-8-specific effector and memory T lymphocytes were associated with complete KS remission. In a renal recipient undergoing SRL conversion, the early recovery of HHV-8-specific effector but not of memory T lymphocytes, was associated only with partial remission. Neither rejection nor changes in graft function were observed after SRL conversion. HHV-8-specific T-cell responses are required to achieve posttransplant KS remission, and may be restored under SRL, while maintaining effective immunosuppression.
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