期刊
TRANSPLANT INTERNATIONAL
卷 26, 期 1, 页码 67-74出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1432-2277.2012.01576.x
关键词
body mass index; glycosylated hemoglobin; metabolic syndrome; obesity; risk factors
The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS-associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. De novo MetS affected 32.9% of our cohort (n = 170) within 2 years after OLT. Multivariate analysis identified glycosylated hemoglobin (HbA1c) levels =5% [odds ratio (OR) = 3.5; 95% confidence interval (CI) = 1.568.13, P = 0.003], diabetes mellitus (OR = 4.31, CI = 1.6910.99, P = 0.002), and arterial hypertension (OR = 4.59, CI = 1.4614.49, P = 0.009) as independent risk factors for de novo MetS. MetS incidence correlated with steroid dosage after OLT (5.2 +/- 2.4 mg/day vs. 7.1 +/- 4.7 mg/day, P = 0.014), and was linked to NAFLD (P = 0.001) via obesity (OR = 4.67, CI = 1.5514.1, P = 0.006) and dyslipidemia (OR = 4.23, CI = 1.3513.3, P = 0.013) post-OLT. In conclusion, we were able to identify low threshold HbA1c as a novel risk factor for MetS after OLT and described a link of MetS with NAFLD in transplant organs. This study also indicated that steroid treatment is associated with MetS rates after OLT.
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