期刊
TRANSITION METAL CHEMISTRY
卷 35, 期 6, 页码 713-720出版社
SPRINGER
DOI: 10.1007/s11243-010-9384-8
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Three Ru(II) complexes, namely [Ru(bipy)(2)PRIP](2+) (1), [Ru(dmb)(2)PRIP](2+) (2), and [Ru(phen)(2)PRIP](2+) (3) (dmb = 4,4'-dimethyl-2,2'-bipyridine; PRIP = 2-(pyrrole) imidazo [4,5-f]-1,10-phenanthroline) have been synthesized and characterized by elemental analysis, mass spectra, IR, H-1 NMR and C-13 NMR. The DNA-binding properties of the three complexes with calf-thymus DNA (CT-DNA) were investigated by spectrophotometry, fluorescence methods and viscosity measurements. The results suggest that all three complexes bind to CT-DNA through intercalation. Also, when irradiated at 365 nm, the three complexes promote the photocleavage of plasmid pBR-322 DNA. Under comparable experimental conditions, complex 3 cleaves DNA more effectively than complexes 1 and 2.
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