期刊
TRANSFUSION AND APHERESIS SCIENCE
卷 46, 期 3, 页码 343-346出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.transci.2012.03.027
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- Ablynx NV
The Phase II TITAN trial is designed to assess the efficacy and safety of an anti-von Willebrand factor (vWF) Nanobody in patients with acquired thrombotic thrombocytopenic purpura (TTP). Nanobodies are a novel class of therapeutic proteins and are based on the smallest functional fragments of single-chain antibodies that occur naturally in the Camelidae family (Nanobody (R) and Nanobodies (R) are registered trademarks of Ablynx NV). With vWF implicated in the thrombotic process underlying TTP, an anti-vWF Nanobody may hold significant promise as adjunctive therapy to plasma exchange. Recruitment is currently ongoing, and aims to include a total of 110 patients from countries in Europe, the Middle East, Australia and Northern America. (C) 2012 Elsevier Ltd. All rights reserved.
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