Who should be really considered as a poor mobilizer in the plerixafor era?

Patients with a number of peripheral CD34+ cells <= 20/mu L. have recently been defined in the literature as poor mobilizers. We retrospectively reviewed medical records from a total of 248 patients affected by hematological malignancies or solid tumors undergoing peripheral blood stem cell collection following chemotherapy plus G-CSF. On the basis of the CD34+ cell peak in peripheral blood following mobilization therapy, patients were defined as good mobilizers (group A, CD34+ cells >= 20/mu L), relative poor mobilizers (group B, CD34+ cells <20 and >= 8/mu L) and absolute poor mobilizers (group C, CD34+ cells <8/mu L). One hundred and seventy-seven (71%) patients resulted good mobilizers, 35 (14%) patients relative poor mobilizers and 36(15%) patients absolute poor mobilizers. Target of stem cell collection was >= 2.0 x 10(6) CD34+ cells/kg for each transplantation procedure. All patients in group A, 20 patients in group B (57%) and 1 patient in group C (2.7%) were able to collect >= 2.0 x 10(6) CD34+ cells/kg. The multivariate analysis confirmed that more than three lines of previous chemotherapy and a previous autologous PBSC transplantation negatively affect mobilization of CD34+ cells in peripheral blood. Our data suggest that a number of CD34+ cells <= 20/mu L does not always result in a failed stem cell collection and in fact in our patient series more than 70% of the patients defined as poor mobilizers have indeed collected the minimum number of 2.0 x 10(6) CD34+ cells/kg required for a successful transplantation. The use of new agent such as CXCR4 antagonist plerixafor might further improve mobilization efficacy in such patients. (C) 2012 Elsevier Ltd. All rights reserved.