期刊
TRANSBOUNDARY AND EMERGING DISEASES
卷 62, 期 2, 页码 157-162出版社
WILEY-BLACKWELL
DOI: 10.1111/tbed.12100
关键词
bluetongue; vaccine; RNA detection; post-vaccination; disease freedom
资金
- Veterinary and Agrochemical Research Centre (CODA-CERVA)
- Federal Agency for the Safety of the Food Chain
- EC-ORBI-VAC [KBBE-245266]
Bluetongue virus serotype 8 (BTV-8) was responsible for a large outbreak among European ruminant populations in 2006-2009. In spring 2008, a massive vaccination campaign was undertaken, leading to the progressive disappearance of the virus. During surveillance programmes in Western Europe in 2010-2011, a low but significant number of animals were found weakly positive using BTV-specific real-time RT-PCR, raising questions about a possible low level of virus circulation. An interference of the BTV-8 inactivated vaccine on the result of the real-time RT-PCR was also hypothesized. Several studies specifically addressed the potential association between a recent vaccination and BTV-8 RNA detection in the blood of sheep. Results were contradictory and cattles were not investigated. To enlighten this point, a large study was performed to determine the risks of detection of bluetongue vaccine-associated RNA in the blood and spleen of cattle using real-time RT-PCR. Overall, the results presented clearly demonstrate that vaccine viral RNA can reach the blood circulation in sufficient amounts to be detected by real-time RT-PCR in cattle. This BTV-8 vaccine RNA carriage appears as short lasting.
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