期刊
PROTEIN & CELL
卷 6, 期 4, 页码 254-264出版社
SPRINGER
DOI: 10.1007/s13238-014-0131-3
关键词
cholesterol metabolism; homeostasis; apoE
类别
资金
- National Natural Science Foundation of China [81422015, 91332111, 31371087]
- National Basic Research Program (973 Program) [2014CB548100]
- Fundamental Research Funds for the Central Universities
- NN-CAS Research foundation
- Thousand Young Talents Program
Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life. Cholesterol metabolism in brain is independent from that in peripheral tissues due to blood-brain barrier. The content of cholesterol in brain must be accurately maintained in order to keep brain function well. Defects in brain cholesterol metabolism has been shown to be implicated in neurodegenerative diseases, such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and some cognitive deficits typical of the old age. The brain contains large amount of cholesterol, but the cholesterol metabolism and its complex homeostasis regulation are currently poorly understood. This review will seek to integrate current knowledge about the brain cholesterol metabolism with molecular mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据