期刊
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
卷 104, 期 12, 页码 772-776出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.trstmh.2010.08.006
关键词
Hepatitis; Hepatitis E virus; anti-HEV; epidemiology; risk factors; Cuba
Hepatitis E virus (HEV) infection is an important cause of acute viral hepatitis in tropical and sub-tropical regions that occurs both as epidemic episodes and sporadic cases. The aim of this investigation was to estimate the prevalence of total immunoglobulin (Ig) anti-hepatitis E virus (anti-HEV) and the risk factors associated to two communities in Havana City. Serum samples (n = 469) obtained from healthy individuals with no history of viral hepatitis were screened for total anti-HEV by enzyme immunoassay (EIA). An overall prevalence of 10% (47/469) (95% Cl: 7.52-13.19%) was obtained. Higher anti-HEV prevalence was found in the municipality of Marianao (12.1%) compared to Playa (7.1%). Analysis of risk factors revealed a significant association of total anti-HEV prevalence in age group 41-60 years old, with a risk ratio of 3.21 (95% Cl: 1.09-9.7) (P=0.01). No relation was found between anti-HEV and other variables such as gender, risk occupations, surgery and transfusions. The detection of total anti-HEV in individuals with no overt acute hepatitis suggests the existence of sub-clinical or anicteric HEV infection in these municipalities. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
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