期刊
TRAFFIC
卷 15, 期 10, 页码 1179-1193出版社
WILEY
DOI: 10.1111/tra.12191
关键词
cancer; macromolecular trafficking; mRNA metabolism; neurodegenerative disorders; nucleoli; signaling; stress granules; virus infection
类别
Nucleoli and cytoplasmic stress granules (SGs) are subcellular compartments that modulate the response to endogenous and environmental signals to control cell survival. In our opinion, nucleoli and SGs are functionally linked; they are distant relatives that combine forces when cellular homeostasis is threatened. Several lines of evidence support this idea; nucleoli and SGs share molecular building blocks, are regulated by common signaling pathways and communicate when vital cellular functions become compromised. Together, nucleoli and SGs orchestrate physiological responses that are directly relevant to stress and human health. As both compartments have established roles in neurodegenerative diseases, cancer and virus infections, we propose that these conditions will benefit from therapeutic interventions that target simultaneously nucleoli and SGs.
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