期刊
TRAFFIC
卷 15, 期 2, 页码 141-156出版社
WILEY
DOI: 10.1111/tra.12141
关键词
comparative genomics; eukaryogenesis; molecular evolution; nuclear pore complex; nucleus; protocoatomer
类别
资金
- Wellcome Trust
- MRC [090007/Z/09/Z, MR/K008749/1]
- Marie Curie fellowship
- National Institutes of Health [R21 AI096069, U54 GM103511, U01 GM098256]
- MRC [MR/K008749/1] Funding Source: UKRI
- Medical Research Council [MR/K008749/1] Funding Source: researchfish
The nucleus is the defining intracellular organelle of eukaryotic cells and represents a major structural innovation that differentiates the eukaryotic and prokaryotic cellular form. The presence of a nuclear envelope (NE) encapsulating the nucleus necessitates a mechanism for interchange between the contents of the nuclear interior and the cytoplasm, which is mediated via the nuclear pore complex (NPC), a large protein assembly residing in nuclear pores in the NE. Recent advances have begun to map the structure and functions of the NPC in multiple organisms, and to allow reconstruction of some of the evolutionary events that underpin the modern NPC form, highlighting common and differential NPC features across the eukaryotes. Here we discuss some of these advances and the questions being pursued, consider how the evolution of the NPC has been constrained, and finally propose a model for how the NPC evolved.
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