期刊
TRAFFIC
卷 14, 期 6, 页码 622-628出版社
WILEY
DOI: 10.1111/tra.12051
关键词
endoplasmic reticulum quality control; membrane proteins; plant-protein sorting; plant vacuole; storage vacuoles; tonoplast; vesicle traffic
类别
资金
- European Union Marie Curie Research Training Network Vacuolar Transport Equipment for Growth Regulation of Plants [MRTN-CT-2006-035833]
- Italian Ministry of Education, Universities and Research [PRIN2010CSJX4F]
- Swiss National Science Foundation [SNF 31003A_127340]
- Swiss National Science Foundation (SNF) [31003A_127340] Funding Source: Swiss National Science Foundation (SNF)
Tonoplast, the membrane delimiting plant vacuoles, regulates ion, water and nutrient movement between the cytosol and the vacuolar lumen through the activity of its membrane proteins. Correct traffic of proteins from the endoplasmic reticulum (ER) to the tonoplast requires (i) approval by the ER quality control, (ii) motifs for exit from the ER and (iii) motifs that promote sorting to the tonoplast. Recent evidence suggests that this traffic follows different pathways that are protein-specific and could also reflect vacuole specialization for lytic or storage function. The routes can be distinguished based on their sensitivity to drugs such as brefeldin A and C834 as well as using mutant plants that are defective in adaptor proteins of vesicle coats, or dominant-negative mutants of Rab GTPases.
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