期刊
TRAFFIC
卷 13, 期 9, 页码 1187-1197出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0854.2012.01344.x
关键词
Brucella; Chlamydia; endosomal pathway; Golgi apparatus; Legionella; pathogen vacuole; Salmonella; secretory pathway; type III secretion system; type IV secretion system; vesicle trafficking
类别
资金
- Max von Pettenkofer Institute, Ludwig-Maximilians University
- 'Bundesministerium fur Bildung und Forschung' (BMBF) 'Medical Infection Genomics' initiative [0315834C]
- Deutsche Forschungsgemeinschaft (DFG) [HI 1511/1-1, SFB914, SPP1580, SFB645, SFB670]
- Munich
Eukaryotic cells possess two extensive endomembrane systems, each consisting of several sub-compartments connected by vesicular trafficking. One of these systems, the endocytic pathway, serves incoming traffic, and the other system, the secretory pathway (SP), is responsible for surface-bound traffic of intracellularly formed vesicles. Compartments derived of either system can be colonized by intracellular pathogens. In this review, we discuss the interactions between the SP and prominent intracellular bacterial pathogens of the genera Legionella, Brucella, Chlamydia and Salmonella. We emphasize secreted bacterial effector proteins, which directly manipulate host components of this pathway.
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