期刊
TRAFFIC
卷 13, 期 2, 页码 329-337出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0854.2011.01305.x
关键词
EGF receptor; intraluminal vesicles; multivesicular bodies; recycling; ubiquitination
类别
资金
- CRUK [C20675]
- MRC [G0801878]
- Wellcome Trust [078304]
- NIH [CA089151, CA112219]
- MRC [G0801878] Funding Source: UKRI
- Medical Research Council [G0801878] Funding Source: researchfish
Progression of activated EGF receptor (EGFR) through the endocytic pathway regulates EGFR signaling. Here we show that a non-ubiquitinated EGFR mutant, unable to bind the endosomal-sorting complex required for transport (ESCRT) component, Hrs, is not efficiently targeted onto intraluminal vesicles (ILVs) of multivesicular endosomes/bodies (MVBs). Moreover, ubiquitination and ESCRT engagement of activated EGFR are required for EGF-stimulated ILV formation. Non-ubiquitinated EGFRs enter clathrin-coated tubules emanating from MVBs and show enhanced recycling to the plasma membrane, compared to wild-type EGFR.
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