期刊
TRAFFIC
卷 12, 期 12, 页码 1669-1676出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0854.2011.01251.x
关键词
antigen presentation; costimulation; cross-presentation; C-type lectin receptors; dendritic cells; MHC class I; MHC class II; pattern recognition receptors; toll-like receptors; trafficking
类别
资金
- NIAID NIH HHS [R56 AI073899, R01 AI123284, R01 AI073899] Funding Source: Medline
Dendritic cells are innate sentinels of the immune system and potent activators of naive T cells. Mechanisms must exist to enable these cells to achieve maximal activation of T cells specific for microbial antigens, while avoiding activation of T cells specific for self-antigens. Here we discuss how a combination of signals from pattern recognition receptors and T cells co-ordinates subcellular trafficking of antigen with both major histocompatibility complex class I and class II molecules and T-cell costimulatory molecules, resulting in the preferential presentation of microbial peptides within a stimulatory context.
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