期刊
TRAFFIC
卷 11, 期 10, 页码 1265-1271出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0854.2010.01076.x
关键词
exosomes; lipid modification; morphogen gradient; retromer; Wnt secretion; Wntless
类别
资金
- Forschungskredit of the University of Zurich
- Swiss National Science Foundation
- Kanton of Zurich
Proteins of the Wnt family are secreted signaling molecules that regulate multiple processes in animal development and control tissue homeostasis in the adult. Wnts spread over considerable distances to regulate gene expression in cells located at distant sites. Paradoxically, Wnts are poorly mobile because of their posttranslational modification with lipids. Recent evidence suggests that several pathways exist that are capable of transforming hydrophobic, insoluble Wnts into long-range signaling molecules. Furthermore, the discovery of Wntless as a protein specifically required for the secretion of Wnt suggests that Wnt trafficking through the secretory pathway is already under special scrutiny. Here, we review recent data on the molecular machinery that controls Wnt secretion and discuss how Wnts can be mobilized for long-range signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据