期刊
TRAFFIC
卷 10, 期 9, 页码 1209-1220出版社
WILEY
DOI: 10.1111/j.1600-0854.2009.00922.x
关键词
adaptor; clathrin; endocytosis; network; signalling; transcription
类别
资金
- EU/Marie Curie Cancer Cure Early Stage Research Training (CANCURE) Fellowship
- Cancer Research UK Programme
- University of Cambridge
- Cancer Research UK
- Hutchison Whampoa Limited
- National Institute for Health Research (NIHR)
- MRC [G0500966] Funding Source: UKRI
- Medical Research Council [G0500966] Funding Source: researchfish
A subset of proteins predominantly associated with early endosomes or implicated in clathrin-mediated endocytosis can shuttle between the cytoplasm and the nucleus. Although the endocytic functions of these proteins have been extensively studied, much less effort has been expended in exploring their nuclear roles. Membrane trafficking proteins can affect signalling and proliferation and this can be achieved either at a nuclear or endocytic level. Furthermore, some proteins, such as Huntingtin interacting protein 1, are known as cancer biomarkers. This review will highlight the limits of our understanding of their nuclear functions and the relevance of this to signalling and oncogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据