期刊
TRAFFIC
卷 11, 期 1, 页码 8-15出版社
WILEY
DOI: 10.1111/j.1600-0854.2009.00971.x
关键词
clathrin adaptor AP-2; endocytosis; Eps15; stonin; synaptic vesicles; synaptotagmin
类别
资金
- DFG [Exc 257-Neurocure, HA2686/4-1/SFB 740, HA2686/3-1/FG806]
Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2 mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves as a linker between the endocytic proteins AP-2 and Eps15 and the calcium-sensing synaptic vesicle (SV) protein synaptotagmin 1. The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin 2 are evolutionarily conserved from worm to man, thereby identifying stonin 2 and its invertebrate homologs uncoordinated (UNC)-41 and stoned B as endocytic adaptors dedicated to the retrieval of surface-stranded SV proteins, most notably synaptotagmin. In this review, we summarize the current state of knowledge about mammalian stonins with a special focus on the role of stonin 2 in SV recycling at presynaptic nerve terminals.
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