期刊
TRAFFIC
卷 9, 期 5, 页码 657-664出版社
WILEY
DOI: 10.1111/j.1600-0854.2008.00728.x
关键词
Apicomplexa; dense granules; membranous nanotubular network; parasitophorous vacuole; Plasmodium spp; rhoptries; Toxoplasma gondii; tubovesicular network
类别
Most Apicomplexa reside and multiply in the cytoplasm of their host cell, within a parasitophorous vacuole (PV) originating from both parasite and host cell components. Trafficking of parasite-encoded proteins destined to membrane compartments beyond the confine of the parasite plasma membrane is a process that offers a rich territory to explore novel mechanisms of protein-membrane interactions. Here, we focus on the PVs formed by the asexual stages of two pathogens of medical importance, Plasmodium and Toxoplasma. We compare the PVs of both parasites, with a particular emphasis on their evolutionary divergent compartmentalization within the host cell. We also discuss the existence of peculiar export mechanisms and/or sorting determinants that are potentially involved in the post-secretory targeting of parasite proteins to the PV subcompartments.
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