期刊
TRAFFIC
卷 9, 期 9, 页码 1437-1445出版社
WILEY
DOI: 10.1111/j.1600-0854.2008.00775.x
关键词
dendritic growth; local protein translation; neuron; polarized trafficking; postsynaptic receptors; secretory pathway; spine apparatus
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NINDS NIH HHS [R01 NS039402-06, R01 NS039402-08, R01 NS039402, R01 NS039402-10, R01 NS039402-09, R01 NS039402-07] Funding Source: Medline
The large size and geometric complexity of neuronal dendrites necessitate specialized mechanisms to both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in dendrite growth, synapse formation and plasticity, the organelles and cellular rules governing postsynaptic trafficking are only now emerging. Here we review what is currently known about dendritic secretory organelles and their role in the development, maintenance and plasticity of postsynaptic compartments.
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