期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 54, 期 -, 页码 24-35出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2013.11.002
关键词
5-Carboxylcytosine; 5-Formylcytosine; 5-Hydroxymethylcytosine; 5-Methylcysine; Disease biology; DNA methylation; Epigenetic modification; Genome-wide distribution analysis; Overall analysis; Oxidation product
资金
- National Basic Research Program of China (973 Program) [2012CB720601, 2013CB910702]
- National Natural Science Foundation of China [91217309, 91017013, 31070327, 21205091, 21228501]
DNA methylation (5-methylcytosine, 5-mC) is an important epigenetic mark that has regulatory roles in a broad range of biological processes and diseases. Aberrant DNA methylation is associated with a wide variety of human diseases. Recently, novel cytosine modifications with potential regulatory roles, such as 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-foC), and 5-carboxylcytosine (5-caC), were discovered. Systematic investigation of the functions of 5-mC and its oxidation products promotes understanding of the mechanism underlying association of epigenetic modifications with disease biology. In this respect, remarkable advances have been made in developing methods for investigating the occurrence and the localization of these cytosine modifications. In this review, we mainly focus on the recent methodological advances in the analysis of the total levels of 5-mC and its oxidation products (5-hmC, 5-foC and 5-caC). In addition, we summarize and discuss new methods for mapping the genome-wide distribution of 5-hmC, 5-foC and 5-caC. (C) 2013 Elsevier Ltd. All rights reserved.
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