期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 53, 期 -, 页码 11-20出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2013.08.007
关键词
Aptamer; Bioanalytical application; Biosensor; DNA hairpin; DNA hairpin-based fluorescent probe (DHFP); Dye molecule; Fluorescent probe; Molecular beacon (MB); Nanomaterial; Signal transduction
资金
- National Natural Science Foundation of China [21190041, 21190044, 21205032]
- National Natural Science Foundation of Post-doctoral Scientists of China [2013M531779]
- International Science & Technology Operation Program of China [2010DFB30300]
- Program for New Century Excellent Talents in University [NCET-09-0338]
- Hunan Provincial Natural Science Foundation of China [13JJ4032]
DNA hairpin-based fluorescent probes (DHFPs) are widely used in molecular biology, biosensor development, mRNA monitoring in living cells and imaging in vivo. In this review, we focus on the typical designs and the recent bioanalytical applications of DHEPs. We describe the application of different materials with excellent photophysical properties as signal labels to reduce the background and to increase the brightness of the DHFPs. These labels range from dye molecules to nanomaterials. We also discuss the general design of signal-transduction mechanisms. (C) 2013 Elsevier Ltd. All rights reserved.
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