期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 45, 期 -, 页码 154-168出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2012.11.012
关键词
Ambient mass spectrometry; Biological system; Biosensor; In vivo; Lab-on-a-chip; Microanalysis; Microextraction; Microsampling; Simulation; Spectroscopy
This article reviews recent developments in in-vivo sampling and sample preparation for analysis of biological systems. The trend towards microanalytical techniques is justified by the small amount of sample that is available from some biological systems and the need to minimize interference with the system that is being studied or analyzed. Different approaches to direct in-vivo sampling and sample preparation are described, including microsampling, ultrafiltration, microextraction, microdialysis, solid-phase microextraction, biosensors, ambient mass spectrometry, spectroscopy, and microfluidic devices. (C) 2013 Elsevier Ltd. All rights reserved.
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