期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 49, 期 -, 页码 71-88出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2013.05.006
关键词
Degradation product; Drug substance; Forced degradation; Guideline; Quality by Design (QbD); Pharmacopoeia; Regulatory agency; Stability; Stress testing; World-wide regulatory requirements
A forced degradation study is an essential step in the design of a regulatory compliant stability program for both drug substances and products, and was formalized as a regulatory requirement in ICH Guideline Q1A in 1993. It has since been extended to generic drugs. We provide an update on world-wide regulatory requirements. Also, we list all possible benefits of forced degradation studies to assess the stability of drugs and products. We discuss the kind of forced degradation study likely to meet regulatory expectations. We include the knowledge gained from these studies within the Quality by Design paradigm. (C) 2013 Elsevier Ltd. All rights reserved.
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