High-throughput solid-phase microextraction in multi-well-plate format

This review summarizes different formats of high-throughput, multi-well, solid-phase microextraction (SPME), including fiber, thin-film and in-tip configurations, with the particular focus on its fit within regulated analysis. New developments of the devices, such as monolithic and biocompatible extraction phases, are covered. Finally, selected applications of the technique, including the analysis of whole-blood samples and automated binding studies, are presented. (C) 2013 Elsevier Ltd. All rights reserved.