期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 39, 期 -, 页码 180-194出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2012.07.006
关键词
Biochemical; Chiral stationary phase (CSP); Chromatography; Computational chemistry; Enantioseparation; High-performance liquid chromatography (HPLC); Preparation; Recognition; Rational design; Resolution
资金
- National Basic Research Program of China [2009CB421603]
- National Natural Science Foundations of China [20837002, 21177112]
Chromatography technology based on chiral stationary phases (CSPs) for enantioseparation is widely used for resolution and preparation of biochemicals (e.g., drugs, foods, fragrances and pollutants). In this review, we focus on the development of CSPs for high-performance liquid chromatography (HPLC), including the recognition mechanism, applications and limitations of classical CSPs, newly discovered types of CSP, and also the methods for the rational design of future CSPs on the basis of computational chemistry. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
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