期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 33, 期 -, 页码 81-94出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2011.09.012
关键词
Aptamer; Aptasensor; Biosensor; Chemical-labeling probe; Electrochemical detection; Electrochemiluminescence; Functional nucleic acid; Hybridization; Immobilization; Signal probe
资金
- NSF of China [21075068]
- National Basic Research Program of China (973 Program) [2011CB707703]
- Tianjin Natural Science Foundation [11JCZDJC22200]
Functional nucleic acids (NAs) can act as ligand-binding agents (aptamers) or catalysts (NA enzymes), or have both roles (aptazymes). They have shown capacity for specific molecular recognition of various targets. Electrochemical and electrochemiluminescent (ECL) methodologies have technical simplicity, and good sensitivity and easy adaptability for in-situ analysis with relatively cheap instrumental set-ups. This article reviews NAs for electrochemical and ECL sensing applications in terms of the modification of NAs, and introduction and design of signal probes. It also discusses immobilization of NAs, improvement in signal intensity and decrease in background noise. (C) 2012 Elsevier Ltd. All rights reserved.
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