期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 33, 期 -, 页码 1-8出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2011.09.013
关键词
Breath analysis; Diagnosis; Disease-state monitoring; Environmental exposure; Gas chromatography; Gastrointestinal disease; Helicobacter pylori infection; Lung disease; Metabolic disorder; Volatile organic compound
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology (MEST) [2009-0093848]
In this review, we describe technical developments in breath analysis and its applications in clinical diagnosis, monitoring disease state, and assessing environmental exposure. Breath tests have been successfully employed in clinical analyses for symptoms including lung disease, oxidative stress, gastrointestinal disease, metabolic disorders, and Helicobacter pylori infection. Although gas chromatography has been used mainly for the analysis of volatile constituents in breath samples, other techniques (e.g., sensors and lasers) have also been used satisfactorily. The analytical results of breath analysis can be derived both qualitatively and quantitatively. However, evaluation of the data from different approaches remains insufficient because of the lack of standardized procedures and poor methods of validation. Further research is therefore required to expand the applicability of breath analysis in clinical diagnosis of diseases. (C) 2012 Elsevier Ltd. All rights reserved.
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