期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 30, 期 2, 页码 254-269出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2010.10.011
关键词
Antibody; Aptamer; Binding protein; Biorecognition; Immunoassay; Molecular-imprinted polymer; Nanobody; Protein scaffold; Single-chain variable fragment; Synthetic binder
资金
- European Commission [FOOD-CT-2005-006988 BIOCOP]
- Food for Health Research Initiative
- Health Research Board [07FHRITAFRC5]
- Science Foundation Ireland [05/CE3/B754]
The need for chemical and biological entities of predetermined selectivity and affinity towards target analytes is greater than ever, in applications such as environmental monitoring, bioterrorism detection and analysis of natural toxin contaminants in the food chain. In this review, we focus on advances in the production of specific binders, in terms of both natural entities (e.g., antibodies) and synthetic binders (e.g., molecularly-imprinted polymers). We discuss the potential of emerging technologies for integration into immunoassay and sensing techniques. We place special emphasis on use of these technologies in bioanalytical applications. (C) 2010 Elsevier Ltd. All rights reserved.
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